In a large skillet over medium heat, cook the ground beef until no longer pink. Drain off any excess fat. Stir in the garlic powder, onion powder, oregano, cumin, salt and pepper. Set aside.
Heat the oil in the same skillet over medium heat. Add the onion and garlic; cook and stir until softened. Stir in the chiles, then sprinkle with flour. Cook for 1 minute.
Stir in the beef broth and bring to a boil. Reduce heat to low and simmer until thickened.
Add the beef mixture to the pan and stir to combine.
Preheat oven to 350 degrees F (175 degrees C). Grease a baking sheet.
Divide dough into 12 pieces. Roll each piece into a round about 6 inches in diameter. Place about 2 tablespoons of filling onto one half of each round.
Fold dough over filling; press edges together with a fork to seal.
Place empanadas onto prepared baking sheet; brush tops with melted butter or margarine.
Bake for 25 minutes in preheated oven or until golden brown.