Preheat oven to 400 degrees F (200 degrees C). Line a baking sheet with parchment paper.
Spread the French fries onto the prepared baking sheet. Bake in preheated oven for 15 minutes or until golden brown and crispy.
Meanwhile, heat a large skillet over medium-high heat. Add the ground beef and onion; cook and stir until the beef is crumbly, evenly browned, and no longer pink.
Drain off any excess grease. Stir in the chili powder, garlic powder, salt, and pepper.
Top the cooked French fries with the beef mixture. Serve hot.